Thiazole derivatives

Details Thiazole derivatives Thiazole derivatives

C - Chemistry, Metallurgy

07

D

167/211, 260/266

C07D 417/04 (2006.01) A61K 31/44 (2006.01) C07D 413/04 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2001867

Abstract The invention relates to thiazole derivatives with the general formula I Image I wherein R1 is halogen, CF3, CN, NO2, OH or C1-C6 alkoxy; R2 is hydrogen, C1-C6 alkyl, C1-C6 alkoxy, aryl, C6-C13 aralkyl, an unsubstituted amino group, a substituted amino group, or an amino group which is part of a 5- or 6-membered ring; R3 is C1-C6 hydrocarbon, C6-C13 aralkyl, C2-C7 alkoxy- alkyl or C1-C13 acyl; and their pharmaceutically acceptable acid addition salts. These new compounds have .alpha.2-antagonist activity without dopamine agonist activity and as such are specifically useful for the treatment of depression and other related illnesses, e.g. for treating patients with anxiety disorders and cognitive disturbances.

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