Thiazole derivatives

Details Thiazole derivatives Thiazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 277/40 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) C07D 209/48 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2074180

2074180 9110657 PCTABS00006 A N-[.omega.-(thiazol-4 or 5-yl)alkyl]isourea, isothiourea of a guanidine derivative with formula (II) and a N-(.omega.-substituted alkyl)-N'-substituted-N''-[.omega.-(thiazol-4 or 5-yl)alkyl]-guanidine with formula (III), a process for the preparation of said compounds by ring closure of a 2-bromo-.omega.-phthalimidoalkanal, or of a 3-bromo or 1-bromo .omega.-phthalimidoalkan-2-one with thioformamide, an alkylthioamide or thiourea followed by hydrazinolysis or hydrolysis of the resulting phthalimido derivates and medicaments containing said derivatives with formulas (II) and (III) and use of said medicaments for the treatment of congestive heart diseases or for the treatment of allergic disorders.

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