Thiazole derivatives

Details Thiazole derivatives Thiazole derivatives

C - Chemistry, Metallurgy

07

D

260/302, 260/310

C07D 277/36 (2006.01)

Patent

CA 1045136

ABSTRACT OF THE DISCLOSURE Novel thiazole derivatives of the formula (I); Image (I) wherein R1 and R2 are each hydrogen, lower alkyl, cycloalkyl, optionally substituted aryl or optionally substituted hetero- aromatic ring containing any one or more of oxygen, sulfur, or nitrogen, and R3 and R4 are each hydrogen or lower alkyl, and salts thereof, may be prepared by reacting a thiazole derivative of the formula (II) Image (II) wherein R1 and R2 have the same meanings as defined above and A is Image or Image where X is a halogen, with an amino of the formula (III) HNR3R4 (III) wherein R3 and R4 have the same meanings as defined above The thiazole derivatives of the formula (I) have excellent pharmacological properties, such as .beta.-adrenergic receptor blocking effect, with low toxicity, and are valuable compounds exerting preventive or therapeutic effect on heart diseases, for example, arrhythmia, angina pectoris and other coronary heart diseases.

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