Thiazole derivatives and production thereof

Details Thiazole derivatives and production thereof Thiazole derivatives and production thereof

C - Chemistry, Metallurgy

07

D

260/308.5

C07D 277/32 (2006.01) C07D 277/34 (2006.01) C07D 277/36 (2006.01) C07D 277/42 (2006.01) C07D 277/56 (2006.01)

Patent

CA 1051906

A B S T R A C T Thiazole derivatives represented by the general formula: Image wherein A is oxygen, sulfur, imino or NR3; R3 is alkyl, alkenyl, alkynyl, cycloalkylalkyl or aralkyl; R1 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkylalkyl or aralkyl; R2 is hydroxy, ester residue or OM; M is alkali metal, one-equivalent of alkaline earth metal, cupric or aluminium cation; n is an integer of 0 or 1 and the thiazole ring may have one or two substituents selected from alkyl or halogen and the benzene ring may have one or two substituents selected from halogen, alkyl, alkoxy or trifluoro- methyl synthesized by condensation with halogenothiazole or carboxylation being useful as anti-inflammatory, anti-rheumatic, analgesic or anti-lipemia agents.

211104

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