C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/68 (2006.01) A61K 31/425 (2006.01) A61P 25/00 (2006.01) C07D 277/56 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2462692
The present invention relates to a group of thiazole derivatives which are potent antagonists, agonists or partial agonists of the cannabinoid CB1- receptor. The compounds have the general formula (I) wherein R and R1-R4 have the meanings given in the specification.
L'invention concerne un groupe de dérivés de thiazole qui sont de puissants antagonistes vis-à-vis du récepteur cannabinoïde CB¿1?, ou de puissants agonistes ou agonistes partiels vis-à-vis de ce récepteur. Les composés considérés sont représentés par la formule générale (I), pour les besoins de laquelle R et R¿1?-R¿4? ont l'acception définie dans la description.
Dijksman Jessica A. R.
Herremans Arnoldus H. J.
Kruse Cornelis G.
Lange Josephus H. M.
Mccreary Andrew C.
Fetherstonhaugh & Co.
Solvay Pharmaceuticals B.v.
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