C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/211, 167/234
C07D 277/32 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) C07D 277/40 (2006.01) C07D 277/46 (2006.01) C07D 277/54 (2006.01) C07D 277/56 (2006.01) C07D 417/02 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2022731
ABSTRACT OF THE DISCLOSURE Compounds of the formula Image (I) wherein R1 is hydrogen or acyl which may be substituted with halogen, R2 is hydrogen, lower alkyl, hydroxy(lower)alkyl, halogen or carboxy, A is -CH2-, -CO-, -C(=NOR4)- [wherein R4 is lower alkyl], Image or Image [wherein m is 0, 1 or 2], and R3 is aryl which may be substituted with halogen, hydroxy, lower alkoxy, nitro, amino or acylamino; or N-containing unsaturated heterocyclic group which may be substituted with lower alkyl, amino, hydroxy or halo(lower)alkyl, and pharmaceutically acceptable salts thereof. A process for the preparation of these compounds, pharmaceutical compo- sitions containing them as well as the treatment of rheumatism, nephritis, thrombocytopenia, tumor and side effect of an antitumor agent are also described.
Igari Norihiro
Matsuo Masaaki
Ogino Takashi
Seno Hachiro
Shimomura Kyoichi
Fujisawa Pharmaceutical Co. Ltd.
Swabey Ogilvy Renault
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