Thiazole pyrazolopyrimidines as crf1 receptor antagonists

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 487/04 (2006.01) A61K 31/505 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61P 25/30 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2663511

The present invention relates to compounds of Formula (I), pharmaceutical compositions thereof, and use thereof as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric and neuroendocrine disorders, neurological diseases, and metabolic syndrome.

La présente invention concerne des composés représentés par la formule (I), des compositions pharmaceutiques à base de ces composés, et leur utilisation comme antagonistes du récepteur du CRF1 (facteur 1 de libération de la corticotropine) pour le traitement de troubles psychiatriques et neuroendocriniens, de maladies neurologiques et du syndrome métabolique.

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