Thiazoles and oxazoles useful as modulators of atp-binding...

Details Thiazoles and oxazoles useful as modulators of atp-binding... Thiazoles and oxazoles useful as modulators of atp-binding...

C - Chemistry, Metallurgy

07

D

C07D 277/56 (2006.01) A61K 31/42 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) C07D 263/34 (2006.01) C07D 417/04 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2545719

The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

L'invention concerne des modulateurs de transporteurs de type cassette de liaison à l'ATP (<= ABC >=) ou des fragments de ceux-ci, notamment le régulateur transmembranaire de fibrose kystique (<= CFTR >=), des compositions associées, et des procédés faisant intervenir ceux-ci. L'invention concerne également des procédés de traitement de maladies dont la médiation est assurée par le transporteur ABC faisant intervenir lesdits modulateurs.

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