Thiazoles as 11 beta-hsd1 inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 277/56 (2006.01) A61K 31/427 (2006.01) A61P 3/00 (2006.01) A61P 37/00 (2006.01) C07D 417/06 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2636826

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.

La présente invention concerne des composés de formule (I) : , dans laquelle les substituants sont ceux divulgués dans le mémoire descriptif, ainsi que leurs sels pharmaceutiquement acceptables. Ces composés et les compositions pharmaceutiques qui les contiennent sont utilisables pour le traitement de maladies telles que le diabète sucré de type II ou le syndrome métabolique, par exemple.

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