A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/541 (2006.01) C07D 277/14 (2006.01) C07D 417/04 (2006.01)
Patent
CA 2758202
The present invention relates to thiazolidin-4-one and [1,3]-thiazinan-4-one compounds of formula (I) wherein X, Y, R3 and R4 are as described in the description, or pharmaceutically acceptable salts thereof, for the prevention or treatment of diseases related to the orexin system. The present invention also relates to novel thiazolidin-4-one compounds of formula (II) and their use as pharmaceuticals, pharmaceutical compositions containing one or more compounds of formula (II), and especially their use as orexin receptor antagonists.
La présente invention concerne des composés thiazolidin-4-one et [1,3]-thiazinan-4-one de formule (I) dans laquelle X, Y, R3 et R4 sont tels que définis dans la description, ou leurs sels pharmaceutiquement acceptables, pour la prévention ou le traitement de maladies liées au système de l'oréxine. La présente invention concerne également de nouveaux composés thiazolidin-4-one de formule (II) et leur utilisation comme produits pharmaceutiques, les compositions pharmaceutiques contenant un ou plusieurs composés de formule (II), et particulièrement leur utilisation comme antagonistes des récepteurs à l'oréxine.
Aissaoui Hamed
Boss Christoph
Brotschi Christine
Gatfield John
Gude Markus
Actelion Pharmaceuticals Ltd
Gowling Lafleur Henderson Llp
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