Thiazolidine-2,4-dione derivative, salt thereof, and...

Details Thiazolidine-2,4-dione derivative, salt thereof, and... Thiazolidine-2,4-dione derivative, salt thereof, and...

C - Chemistry, Metallurgy

07

D

C07D 277/34 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2081113

The present invention provides novel thiazolidine-2,4-dione derivatives possessing blood sugar-lowering action and aldose reductase-inhibitory action, their salts, their preparative processes and drugs containing them, and relates to thiazolidine-2,4-dione derivatives represented by a general formula (1) (see formula I) [wherein R1 and R2 denote identically or differently hydrogen atoms or lower alkyl groups, R3 denotes a phenyl group, naphthyl group, benzoyl group or 5-membered or 6-membered heteroring and its benzene-condensed ring, which may have one or more substituents, A denotes a carbonyl group, sulfonyl group or bonding hand, and B denotes a lower alkylene, lower alkenylene or bonding hand], or their salts, or thiazolidine-2,4-dione derivatives represented by a general formula (2) (see formula II) [wherein R4 denotes a hydrogen atom or lower alkyl group, and R1 and R3 are same as above], or their salts.

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