Thiazolidine derivatives, process for preparing same and...

Details Thiazolidine derivatives, process for preparing same and... Thiazolidine derivatives, process for preparing same and...

C - Chemistry, Metallurgy

07

D

167/234, 260/302

C07D 417/06 (2006.01) A61K 31/425 (2006.01) C07D 277/06 (2006.01)

Patent

CA 1331617

S P E C I F I C A T I O N Title: NEW THIAZOLIDINE DERIVATIVES, PROCESS FOR PREPARING SAME AND ANTI-AMNESTIC COMPOSITION CONTAINING SAME ABSTRACT OF THE DISCLOSURE New thiazolidine derivatives of the general formula: Image wherein X stands for a proline or thioproline residue and R for -CH2OH or -CHO, a process for preparing same which comprises reacting N-benzyloxycarbonyl-L-proline or -L-thioproline with L- thioprolinol and, if necessary, oxidizing the resultant N- benzyloxycarbonyl-L-prolyl-L-thioprolinol or -L-thioprolyl-L- thioprolinol to the corresponding thioprolinal compound, and an anti-amnestic composition containing at least one of the thiazolidine derivatives together with a conventional excipient. The new thiazolidine derivatives are extremely strong in anti- amnestic activity as compared with known similar anti-amnestic agents.

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