Thiazolidinedione analogues for the treatment of hypertension

Details Thiazolidinedione analogues for the treatment of hypertension Thiazolidinedione analogues for the treatment of hypertension

C - Chemistry, Metallurgy

07

D

C07D 277/34 (2006.01) A61K 31/425 (2006.01) A61P 9/12 (2006.01)

Patent

CA 2699289

The present invention relates to thiazolidinedione analogues that are useful for treating hypertension, diabetes, and inflammatory diseases. Formula (I), wherein: each of R1 and R4 is independently selected from H, halo, aliphatic, and alkoxy, wherein the aliphatic and alkoxy are optionally substituted with 1-3 of halo; R2 is halo, hydroxy, or optionally substituted aliphatic, and R'2 is H, or R2 and R'2 together form oxo; R3 is H; and Ring A is a phenyl.

La présente invention concerne des analogues de thiazolidinedione représentés par la formule (I) qui sont utiles pour le traitement de l'hypertension, du diabète et des maladies inflammatoires. Dans la formule (I), chacun de R1 et R4 est sélectionné indépendamment dans le groupe constitué par H, halo, aliphatique et alcoxy, aliphatique et alcoxy étant éventuellement substitué par 1-3 de halo; R2 représente halo, hydroxy, ou éventuellement aliphatique substitué, et R'2 représente H, ou R2 et R'2 forment ensemble oxo; R3 représente H; et un cycle A représente un phényle.

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