Thiazolidinedione derivatives

Details Thiazolidinedione derivatives Thiazolidinedione derivatives

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/425 (2006.01) C07D 277/34 (2006.01)

Patent

CA 2095146

2095146 9207839 PCTABS00013 A compound of formula (I) or a tautomeric form thereof and/or a pharmaceutically acceptable salt thereof, and/or a pharmaceutically acceptable solvate thereof, wherein R1 and R2 each independently represent an alkyl group, a substituted or unsubstituted aryl group or an aralkyl group being substituted or unsubstituted in the aryl or alkyl moiety; or R1 together with R2 represents a linking group, the linking group consisting of an optionally substituted methylene group and either a further optionally substituted methylene group or an O or S atom, optional substituents for the said methylene groups being selected from alkyl, aryl or aralkyl or substituents of adjacent methylene groups together with the carbon atoms to which they are attached form a substituted or unsubstituted phenylene group; R3 and R4 each represent hydrogen, or R3 and R4 together represent a bond; A1 represents a benzene ring having in total up to three optional substituents; X represents O or S; and n represents an integer in the range of from 2 to 6; a process for preparing such a compound, a pharmaceutical composition containing such a compound and the use of such a compound and composition in medicine.

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