Thiazolidinedione derivatives as pi3 kinase inhibitors

Details Thiazolidinedione derivatives as pi3 kinase inhibitors Thiazolidinedione derivatives as pi3 kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/4709 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2649224

Invented is a method of inhibiting the activity/function of PI3 kinases using thiazolidinedione derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of thiazolidinedione derivatives.

L'invention concerne une méthode destinée à inhiber l'activité/fonction des kinases PI3 au moyen de dérivés de thiazolidinedione. L'invention concerne également une méthode de traitement d'un ou plusieurs états pathologiques choisis parmi les troubles auto-immuns, les maladies inflammatoires, les maladies cardiovasculaires, les maladies neurodégénératives, l'allergie, l'asthme, la pancréatite, la défaillance multiviscérale, les maladies rénales, l'agrégation plaquettaire, le cancer, la motilité du sperme, le rejet de transplantation, le rejet de greffe et les lésions pulmonaires, par administration de dérivés de thiazolidinedione.

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