Thiazolidinedione derivatives, method for preparing the...

C - Chemistry – Metallurgy – 07 – D

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C07D 417/06 (2006.01) A61K 31/425 (2006.01) A61K 31/435 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2193171

A thiazolidinedione derivative represented by the following general formula (I): (see fig. I) (I) [wherein the dotted line represents a single bond or a double bond, the thiazolidinedione ring residue is linked to either of 2-, 3-, 4-, 5- and 6-positions on the indole ring and R represents a group selected from the group consisting of hydrogen atom and alkyl, alkenyl, alkynyl, phenyl, aralkyl, heterocycloalkyl, arylsulfonyl and arylaminocarbonyl groups] or a pharmaceutically acceptable salt thereof exhibits excellent effects of reducing the blood sugar level and of reducing the lipid concentration in blood and is accordingly useful as a therapeutic agent for treating diabates mellitus. These derivatives and pharmaceutically acceptable salt thereof are almost free of any side effect.

érivé de la thiazolidinedione de formule générale (I) : (voir fig. I) (I) où la ligne pointillée représente une liaison unique ou double, le résidu du cycle thiazolidinedione est lié à l'une ou l'autre des positions 2, 3, 4, 5 et 6 du noyau indole et R est un groupe choisi parmi le groupe constitué d'un atome d'hydrogène et de groupes alkyle, alkényle, alkynyle, phényle, aralkyle, hétérocycloalkyle, arylsulfonyle et arylaminocarbonyle ou un sel pharmaceutiquement acceptable de ces derniers; le dérivé se caractérise par d'excellentes propriétés pour ce qui est de la réduction du glucose sanguin et de la réduction de la concentration de lipides dans le sang et, par conséquent, est utile comme agent pour le traitement du diabète sucré. Ces dérivés et leurs sels pharmaceutiquement acceptables sont presque exempts d'effets secondaires.

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