Thiazolidines and oxazolidines substituted by a pyridine...

C - Chemistry – Metallurgy – 07 – D

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C07D 417/00 (2006.01) A61K 31/395 (2006.01) A61K 31/695 (2006.01) C07D 413/14 (2006.01) C07D 417/06 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01) C07D 475/00 (2006.01) C07D 487/04 (2006.01) C07D 491/052 (2006.01) C07D 513/04 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2186381

The present invention provides novel pyridine type thiazolidines and their salts, expressed by formula (I) (wherein X1 is S or O; X2 is S, O or NH; Y is CR6R7, R6 is a hydrogen atom, a C1-C7 alkyl group or a C3-C7 cycloalkyl group, and R7 is a hydrogen atom, a C1-C7 alkyl group or a C3-C7 cycloalkyl group or forms a bond together with R4), or SO2; Z is a C1-C10 alkyl group, a C2-C10 alkenyl group, a C2-C10 alkynyl group, a C3-C7 cycloalkyl group, a C3-C7 cycloalkenyl group (each of said alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl groups may be substituted with at most 3 of hydroxyl, oxo, C1-C7 alkyl and C1-C7 alkoxy groups), a phenyl group, a biphenyl group, an .alpha.- naphthyl group, a .beta.-napthyl group, a benzyl group or a heterocyclic group. The compounds have a hypoglycemic effect.

La présente invention concerne de nouvelles thiazolidines pyridiniques et leurs sels représentés par la formule générale (I). Dans cette formule générale (I): X?1¿ représente S ou O, X?2¿ représente S, O ou NH; Y représente CR?6¿R?7¿ ou SO¿2? (R?6¿ étant un atome d'hydrogène, un groupe C¿1?-C¿7? alkyle ou un groupe C¿3?-C¿7? cycloalkyle, R?7¿ étant un atome d'hydrogène, un groupe C¿1?-C¿7? alkyle ou un groupe C¿3?-C¿7? cycloalkyle, ou constituant une liaison avec R¿4?); Z représente un groupe C¿1?-C¿10? alkyle, un groupe C¿2?-C¿10? alkényle, un groupe C¿2?-C¿10? alkynyle, un groupe C¿3?-C¿7? cycloalkyle, un groupe C¿3?-C¿7? cycloalkényle (chacun desdits groupes alkyle, alkényle, alkynyle, cycloalkyle et cycloalkényle pouvant être substitués par 3 groupes au maximum appartenant à l'ensemble constitué par les groupes hydroxyle, oxo, C¿1?-C¿7? alkyle et C¿1?-C¿7? alkoxy), un groupe phényle, un groupe diphényle, un groupe .alpha.-naphthyle, un groupe .beta.-naphthyle, un groupe benzyle ou un groupe hétérocyclique. Ces composés ont un effet hypoglycémiant.

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