Thiazolidinone compounds or angina pectoris remedy or...

C - Chemistry – Metallurgy – 07 – D

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07D 277/14 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) C07D 263/20 (2006.01) C07D 263/24 (2006.01) C07D 277/30 (2006.01) C07D 413/00 (2006.01) C07D 413/04 (2006.01) C07D 413/12 (2006.01) C07D 417/00 (2006.01) C07D 417/04 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2207794

Constitution: a thiazolidinone compound represented by general formula (I) or a pharmacoligically acceptable salt thereof, wherein W represents sulfur or oxygen and X represents -N(R1)-, or alternatively X represents sulfur or oxygen and W represents -N(R1)-, and R1 represents hydrogen, alkyl or substituted alkyl; R2 and R3 are the same or different from each other, and each represents hydrogen, alkyl, substituted alkyl, aryl, or 5- or 6- membered heteroaryl; R4 represents hydrogen, alkyl or substituted C1-C4 alkyl; R5 represents substituted cycloalkyl which may contain nitrogen, provided the substituents include -B-ONO2 (wherein B represents a single bond or alkylene) as the indispensable member and alkyl groups as optional members; and A represents a single bond or alkylene. Effect: the compound has an excellent anti-anginal effect and thus is useful as an angina pectoris remedy or preventive.

L'invention concerne un composé thiazolidinone représenté par la formule générale (I) ou les sels de celui-ci acceptables sur le plan pharmaceutique. Dans cette formule, W représente le soufre ou l'oxygène et X représente -N(R?1¿)- ou encore X représente un soufre ou un oxygène et W représente -N(R?1¿)- et R?1¿ représente un hydrogène, un alkyle ou un alkyle substitué; R?2¿ et R?3¿ sont identiques ou différents et chacun représente un hydrogène, un alkyle, un alkyle substitué, un aryle ou un hétéroaryle à 5 ou 6 éléments; R?4¿ représente un hydrogène, un alkyle substitué ou un C¿1?-C¿4? alkyle; R?5¿ représente un cycloalkyle substitué qui peut contenir un azote, à condition que les substituants contiennent -B-ONO¿2? (où B représente une seule liaison ou un alkylène) comme élément indispensable et des groupes alkyle comme éléments facultatifs; et A représente une liaison simple ou un alkylène. Le composé a un excellent effet anti-angine et il est ainsi utile comme remède pour prévenir ou guérir l'angine de poitrine.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Thiazolidinone compounds or angina pectoris remedy or... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Thiazolidinone compounds or angina pectoris remedy or..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thiazolidinone compounds or angina pectoris remedy or... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-2018655

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.