A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4427 (2006.01) A61K 31/395 (2006.01) A61K 31/42 (2006.01) A61K 31/421 (2006.01) A61K 31/422 (2006.01) A61K 31/425 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61P 1/04 (2006.01)
Patent
CA 2359031
Thia- or oxazolidinone derivatives of formula (II) as defined below, or pharmacologically-acceptable salts thereof, for the treatment or prevention of ulcerative disease: (See formula II) wherein: W represents a sulfur atom or an oxygen atom and X represents a group having the formula -N(R3)-, or X represents a sulfur atom or an oxygen atom and W represents a group having the formula -N(R3)-; R3 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms or an aralkyl group wherein the alkyl group has from 1 to 4 carbon atoms and the aryl group is as defined below; R4 and R5 are the same or different and each represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, an aralkyl group wherein the alkyl group has from 1 to 4 carbon atoms and the aryl group is as defined below, an aryl group as defined below, a 5- or 6-membered aromatic heterocyclic group containing 1 to 3 heteroatoms selected from the group consisting of nitrogen atoms, oxygen atoms and sulfur atoms which may be optionally condensed with a benzene ring or a 5- or 6- membered aromatic heterocyclic group containing 1 to 3 heteroatoms selected from the group consisting of nitrogen atoms, oxygen atoms and sulfur atoms which may be optionally substituted and optionally condensed with a benzene ring, said optional substituents being selected from the group consisting of alkyl groups having from 1 to 6 carbon atoms, amino groups and mono- and di-alkylamino groups wherein the or each alkyl group has from 1 to 6 carbon atoms; R6 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms or an aralkyl group wherein the alkyl group has from 1 to 4 carbon atoms and the aryl group is as defined below; A represents an alkylene group which has from 2 to 6 carbon atoms and which is unsubstituted or is substituted by a substituent selected from the group consisting of carboxyl groups, alkoxycarbonyl groups wherein the alkoxy groups have from 1 to 6 carbon atoms and aryloxycarbonyl groups wherein the aryl group is as defined below; the above-mentioned aryl groups have from 6 to 10 carbon atoms and may be unsubstituted or may be substituted by a substituent selected from the group consisting of alkyl groups having from 1 to 6 carbon atoms, alkoxy groups having from 1 to 6 carbon atoms, hydroxy groups, halogen atoms, amino groups, mono- and di-alkylamino groups wherein the or each alkyl group has from 1 to 6 carbon atoms, and nitro groups.
Fukuda Norio
Ishihara Sadao
Makino Mitsuko
Miyake Shigeki
Ohhata Yasuo
Marks & Clerk
Sankyo Company Limited
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