Thiazolidinones and the use thereof as polo-like kinase...

Details Thiazolidinones and the use thereof as polo-like kinase... Thiazolidinones and the use thereof as polo-like kinase...

C - Chemistry, Metallurgy

07

D

C07D 277/34 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61P 35/00 (2006.01) C07D 231/00 (2006.01) C07D 277/20 (2006.01) C07D 277/82 (2006.01) C07D 417/12 (2006.01) C07D 451/06 (2006.01) C07D 487/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2484597

The invention relates to thiazolidones of general formula (I), in which R1, R2, R3, X and Y have the meanings as cited in the description and wherein represents an E or Z double bond. The invention also relates to the production of these compounds, to their use as inhibitors of the polo-like kinase (PLK) for treating different diseases, and to intermediate products for producing thiazolidones.

L'invention concerne des thiazolidones de la formule générale (I) où R?1¿, R?2¿, R?3¿, X et Y ont les significations données dans la description et où . représente une liaison double E ou Z. L'invention concerne également leur production et leur utilisation comme inhibiteurs de la kinase de type polo (PLK) pour traiter différentes maladies ainsi que des produits intermédiaires destinés à la production des thiazolidones.

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