Thiazolineazetidinone derivatives

Details Thiazolineazetidinone derivatives Thiazolineazetidinone derivatives

C - Chemistry, Metallurgy

07

D

260/298.2

C07D 513/04 (2006.01)

Patent

CA 1097349

CONL-35 THIAZOLINEAZETIDINONE DERIVATIVES Abstract of the Disclosure Thiazolineazetidinone derivatives of the formulae 1,2,and 3. Image Image Image 2 3 wherein R is derived from the commonly known carboxamido groups present in penicillins, R1 is a carboxy protecting group commonly used in penicillin chemistry, and R2 is Cl, Br, I, CN, lower alkoxy, lower acyloxy, SCN, SCH3, S-phenyl, S-heteroaryl such as 5-mercaptotetrazole or 2-mercapto-5-methyl-1,3,4-thiadiazole, NO3, N3, NH- phenyl, and N(CH3)2 with the proviso that R2 in the com- pounds of formula 1 is limited to Cl, Br, I, and lower acyloxy, and a process for preparing said compounds from 2-(substituted methyl) penicillin sulfoxides followed by treatrnent with a base. The compounds of formulae 1,2,and 3 are useful as intermediates in the synthesis of cephalosporins. -1-

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