C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/14 (2006.01) A61K 31/4709 (2006.01) A61P 35/00 (2006.01) C07D 417/06 (2006.01)
Patent
CA 2579476
The present invention relates to thiazolinone monosubstituted quinoline derivatives, where the quinoline ring is mono-substituted at the 4 positions, of formula (I) which derivatives demonstrate CDK 1 antiproliferative activity and are useful as anti-cancer agents; to processes making said derivatives as well as medicaments containing them.
L'invention concerne des dérivés de quinoline monosubstitués par du thiazolinone, le noyau quinoline étant mono-substitué sur les 4 positions, de formule (I). Lesdits dérivés démontrent une activité antiproliférante de la CDK 1 et ils sont utilisés en tant qu'agents anti-cancéreux. L'invention concerne également des procédés pour fabriquer des dérivés ainsi que des médicaments contenant lesdits dérivés.
Chen Li
Chen Shaoqing
Lou Jianping
Sidduri Achyutharao
F.hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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