Thiazoloderivatives and pharmaceutical compositions...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 513/04 (2006.01) A61K 31/4188 (2006.01) A61K 31/519 (2006.01) A61P 25/00 (2006.01) C07D 235/00 (2006.01) C07D 239/00 (2006.01) C07D 277/00 (2006.01)

Patent

CA 2374926

Compounds of formula (I); processes to prepare such compounds; compositions containing such compounds and their use in the treatment of depression, anxiety, psychoses (for examples schizophrenia), tardive dyskinesia, obesity, drug addiction, drug abuse, cognitive disorders, Alzheimer's disease, cerebral ischaemia, obsessive-compulsive behaviour, panic attacks, social phobias, eating disorders such as bulimia, anorexia, snacking and binge eating, non- insulin dependent diabetes mellitus, hyperglycaemia, hyperlipidaemia, stress, and their use in the treatment and/or prophylaxis of seizures, neurological disorders such as epilepsy and/or conditions in which there is neurological damage such as stroke, brain trauma, cerebral ischaemia, head injuries and haemorrhage and as an aid to smoking cessation; are described.

L'invention concerne des composés de la formule (I) et des méthodes de préparation desdits composés. L'invention concerne également des compositions contenant ces composés et leur utilisation dans le traitement de la dépression, de l'anxiété, des psychoses (telles que la schizophrénie), de la dyskinésie tardive, de l'obésité, de la toxicomanie, des dysfonctionnements cognitifs, de la maladie d'Alzheimer, de l'ischémie cérébrale, des troubles obsessifs impulsifs, des crises de panique, des phobies sociales, des troubles alimentaires comme la boulimie, l'anorexie, le grignotage et la frénésie alimentaire, le traitement du diabète sucré non insulino-dépendant, de l'hyperglycémie, de l'hyperlipidémie, du stress. L'invention concerne enfin l'utilisation de ces compositions comme aide au sevrage du tabac ou pour le traitement et/ou la prophylaxie de crises, de troubles neurologiques (tels que l'épilepsie) et/ou de lésions liées à une altération neurologique comme les accidents vasculaires cérébraux, les lésions cérébrales, l'ischémie cérébrale, les traumatismes crâniens et les hémorragies cérébrales.

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