C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 513/04 (2006.01) A61K 31/437 (2006.01) A61K 31/4545 (2006.01) A61K 31/46 (2006.01) A61K 31/4985 (2006.01) A61K 31/4995 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61P 29/00 (2006.01) C07D 519/00 (2006.01) C12N 9/14 (2006.01)
Patent
CA 2721099
Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
L'invention concerne des composés d'amine de thiazolopyridin-2-yloxy-phenyl et de thiazolopyrazin-2-yloxy-phenyl, qui sont utiles en tant que modulateurs de LTA4 hydrolase (LTA4H). De tels composés peuvent être utilisés dans des compositions pharmaceutiques et des procédés de modulation de LTA4H pour le traitement d'état maladifs, de troubles, et d'états régulés par l'activité de LTA4 hydrolase.
Bacani Genesis M.
Broggini Diego
Cheung Eugene Y.
Chrovian Christa C.
Deng Xiaohu
Janssen Pharmaceutica Nv
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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