Thiazolopyrimidine derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 513/04 (2006.01) A61K 31/425 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2120395

ABSTRACT OF THE DISCLOSURE Thiazolopyrimidine derivatives represented by the formula Image and salts thereof are provided, which are characterized by a carboxamide residue substituted with R4 and R5. The derivatives and salts thereof exhibit antiangiogenic activity and are useful for treatment and cure of diseases, the development of which may be related to angiogenesis, including diabetic retinopathy, various chronic inflammation conditions, growth or metastasis of malignant solid tumors, rheumatism and psoriasis. - 118 -

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