C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 513/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2704711
Compounds of Formulas (Ia and Ib), and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including P13K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia and Ib for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
La présente invention concerne des composés de formule Ia et Ib, ainsi que leurs stéréoisomères, isomères géométriques, tautomères, solvates, métabolites et sels acceptables sur le plan pharmaceutique, qui se révèlent utiles en tant qu'inhibiteurs des lipide-kinases dont PI3K, et peuvent être utilisés dans le cadre du traitement d'affections telles que le cancer à médiation par les lipide-kinases. L'invention concerne également des procédés d'utilisation de composés de formule Ia et Ib à des fins de diagnostic in vitro, in situ et in vivo, de prévention ou de traitement desdites affections dans des cellules de mammifère, ou encore de troubles pathologiques associés.
Castanedo Georgette M.
Chuckowree Irina
Folkes Adrian
Gunzner Janet L.
Malesky Kimberly
F. Hoffmann-La Roche Ag
Genentech Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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