Thiazolylpiperidine derivatives as mtp inhibitors

Details Thiazolylpiperidine derivatives as mtp inhibitors Thiazolylpiperidine derivatives as mtp inhibitors

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) A61K 31/454 (2006.01) A61P 3/04 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 491/10 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2531011

The present invention relates to thiazolylpiperidine derivatives of the gen~eral formula (I): in which: A represents a radical chosen from the radicals a1 and a2 below: G represents a bond or a divalent radical chosen from the groups g1, g2 and g3 below: and R1, R2, R2~, R3, R4, R5, Y and Z are as defined in the description. Application of the compounds of the formula (I) to the treatment of hyper~triglyceridaemia, hypercholesterolaemia and dyslipidaemia.

L'invention porte sur des dérivés de la thiazolylpipéridine de formule générale (I) dans laquelle: A représente un radical choisi parmi les radicaux ci-dessous a1 et a2; G représente une liaison ou un radical divalent choisi parmi les groupes g1, g2 et g3 ci-dessous; et R?1¿, R?2¿, R?2'¿, R?3¿, R?4¿, R?5¿, Y et Z sont tels que définis dans la description. Lesdits composés se prêtent au traitement de l'hypertriglycéridémie, de l'hypercholestérolémie et de la dyslipidémie.

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