Thiazolylvinylphenyl derivatives

Details Thiazolylvinylphenyl derivatives Thiazolylvinylphenyl derivatives

C - Chemistry, Metallurgy

07

D

C07D 277/30 (2006.01) A61K 31/425 (2006.01) C07D 277/22 (2006.01) C07D 277/24 (2006.01) C07D 277/28 (2006.01) C07D 277/56 (2006.01) C07D 417/12 (2006.01) C07F 9/6539 (2006.01)

Patent

CA 2099295

ABSTRACT Compounds of the formula: Image I wherein R1 is hydrogen, alkyl, cycloalkyl, carboxyl or alkoxy carbonyl; R2 is hydrogen, halogen or alkyl; A is a group of the formula Image ; Z and W are independently hydrogen or alkyl or Z and W taken together are alkylene; n is an integer of from 0-1; m is an integer of from 0-3; X is -CH2OH or -R4COR5; Y is halogen, alkoxy, acyloxy, hydroxy, alkyl, nitro, trifluoromethyl, hydrogen or cyano; R3 is hydrogen, alkyl or cycloalkyl; R4 is a direct bond or CH2; R5 is hydroxy, alkoxy, NHR6 or Image ; R6 is hydrogen or alkyl; and R7 and R8 are. independently, hydrogen or alkyl or R7 and R8, taken together, are alkylene provided that when m is O and n is O, one of R1 or R3 is cycloalkyl, and enantiomers, diastereomers, racemates and salts with pharmaceutically acceptable bases, antagonize LTD4 action and, thus, are useful in treating bronchial asthma, pulmonary anaphylaxis, cystic fibrosis, chronic bronchitis, bronchiectasis, respiratory distress syndrome and pulmonary oedema.

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