Thieno(2,3-d) pyrimidine derivatives and salts thereof

Details Thieno(2,3-d) pyrimidine derivatives and salts thereof Thieno(2,3-d) pyrimidine derivatives and salts thereof

C - Chemistry, Metallurgy

07

D

260/242.5, 260/2

C07D 495/04 (2006.01)

Patent

CA 1224782

TITLE OF THE INVENTION: THIENO[2,3-d]PYRIMIDINE DERIVATIVES AND SALTS THEREOF ABSTRACT: This invention relates novel thieno[2,3-d]pyrimidine derivatives represented by the following general formula (I): Image or salts thereof; wherein R1 and R2 independently represent hydrogen, halogen or alkyl group having 1 to 6 carbon atoms; or R1 and R2 may concatenate to form a cycloalkylene group having 5 or 6 ring carbon atoms; R3 and R4 independently represent hydrogen or alkyl group having 1 to 6 carbon atoms; R5 represents a member selected from (1) hydrogen or alkyl having 1.to 6 carbon atoms, (2)-(CH2) Image or -(CH2) Image in which m is an integer of from 1 to 3 and X represents halogen, or (3) Image NH-R6 in which R6 represents alkyl group having 1 to 6 carbon atoms; Ar represents subsituted or unsubstituted phenyl, or 2- or 3- thienyl group; and n is 2 or 3. The derivatives of the invention can be used in the treatment of the various depression disease or the higher dysfunction of the brain.

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