Thieno[2,3-d]pyrimidines with combined lh and fsh agonistic...

Details Thieno[2,3-d]pyrimidines with combined lh and fsh agonistic... Thieno[2,3-d]pyrimidines with combined lh and fsh agonistic...

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/505 (2006.01) A61P 15/08 (2006.01)

Patent

CA 2456901

The invention relates to thieno[2,3-d]pyrimidine derivatives according to general formula (I), or a pharmaceutically acceptable salt thereof, wherein N(R1)R2 are joined in a (2-6C)heterocycloalkyl ring. The compounds of the invention have LH as well as FSH receptor activating activity and can be used in fertility regulating therapies.

L'invention concerne des dérivés de thiéno[2,3-d]pyrimidine répondant à la formule générale (I) ou un sel pharmaceutiquement acceptable de ceux-ci, formule dans laquelle N(R1)R2 sont liés entre eux à l'intérieur d'un cycle (2-6C)hetérocycloalkyle. Les composés de l'invention présentent une activité tendant à activer les récepteurs LH ainsi que FSH, et peuvent être utilisés dans des thérapies de régulation de la fertilité.

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