Thieno[3,2-b]pyridine-6-carbonitriles as protein kinase...

Details Thieno[3,2-b]pyridine-6-carbonitriles as protein kinase... Thieno[3,2-b]pyridine-6-carbonitriles as protein kinase...

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/4365 (2006.01)

Patent

CA 2564530

This invention provides compounds of Formula II: wherein: R1, R2 and X are defined hereinbefore in the specification, which are useful in the treatment of cancer, stroke, myocardial infarction, neuropathic pain, osteoporosis, polycystic kidney disease, autoimmune disease, rheumatoid arthritis, and transplant rejection. The invention also provides processes for producing said compounds.

L'invention concerne des composés représentés par la formule II, dans laquelle R1, R2 et X sont définis dans le descriptif. Ces composés sont utiles dans le traitement du cancer, de l'apoplexie, de l'infarctus du myocarde, de la douleur neuropathique, de l'ostéoporose, de la maladie polykystique des reins, des maladies auto-immunes, de la polyarthrite rhumatoïde et d'un rejet de greffe. L'invention concerne également des procédés permettant de produire ces composés.

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