Thieno-and furo-pyrimidine modulators of the histamine h4...

Details Thieno-and furo-pyrimidine modulators of the histamine h4... Thieno-and furo-pyrimidine modulators of the histamine h4...

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/519 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2705719

Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.

L'invention concerne des composés de thiéno- et furo-pyrimidine qui sont utiles comme modulateur du récepteur H4. Ces composés peuvent être utilisés dans des compositions pharmaceutiques et des procédés pour moduler l'activité du récepteur d'histamine H4 et pour le traitement d'états, d'affections et de conditions pathologiques médiés par l'activité du récepteur H4, comme l'inflammation.

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