Thieno-pyridine derivatives as mek inhibitors

Details Thieno-pyridine derivatives as mek inhibitors Thieno-pyridine derivatives as mek inhibitors

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/4365 (2006.01)

Patent

CA 2640594

A series of thieno¢2,3-b!pyridine derivatives which are substituted in the 2- position by a substituted anilino moiety, being selective inhibitors of human MEK (MAPKK) enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, proliferative (including oncological) and nociceptive conditions.

La présente invention concerne une série de dérivés de thiéno[2,3-b]pyridine qui portent une substitution en position 2 par un fragment anilino substitué. Lesdits dérivés sont des inhibiteurs sélectifs des enzymes MEK (MAPKK) humaines et ils présentent donc un intérêt en médecine, par exemple pour le traitement d'états inflammatoires, auto-immunitaires, cardio-vasculaires, prolifératifs (y compris oncologiques) et nociceptifs.

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