Thieno-pyridinone derivatives as kinase inhibitors

Details Thieno-pyridinone derivatives as kinase inhibitors Thieno-pyridinone derivatives as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 221/00 (2006.01) C07D 333/00 (2006.01)

Patent

CA 2540881

A series of thieno[2,3-b]pyridin-6(7H)-one derivatives, substituted in the 3- position by an arylcarbonyl or heteroarylcarbonyl moiety, being inhibitors of p38 MAP kinase, are accordingly of use in medicine, for example in the treatment and/or prevention of immune or inflammatory disorders.

L'invention concerne une série de dérivés de thiéno[2,3-b]pyridin-6(7H)-one, substitués en position 3 par un groupe fonctionnel arylcarbonyle ou un hétéroarylcarbonyle. Ces dérivés sont des inhibiteurs de la kinase MAP p38 et peuvent, par conséquent, être utilisés en médecine, dans le traitement et/ou la prévention de troubles immunitaires ou inflammatoires, par exemple.

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