C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/04 (2006.01) A61K 31/40 (2006.01) A61K 31/42 (2006.01) A61K 31/44 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) A61K 31/55 (2006.01) A61P 25/18 (2006.01) C07D 261/00 (2006.01) C07D 333/00 (2006.01)
Patent
CA 2383327
The compounds of Formula I: (see formula I) are of the class of thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives, useful as D4 antagonists. Said compounds are useful for the treatment of medical conditions mediated by inhibition of D4 receptor. These conditions comprise, for example. Attention Deficit Hyperactivity Disorder, Obsessive-Compulsive Disorder, Psychoses, Substance Abuse, Substance Dependence, Parkinson's Disease, Parkinsonism, Tardive Diskinesia, Gilles de la Tourette Syndrome, Conduct Disorder, and Oppositional Defiant Disorder. A further aspect of the invention is to provide a pharmaceutical composition, intermediates, and a method of making said class of compounds.
L'invention concerne des composés de la classe de dérivés de propyle et d'éthyle nonsubstitués de phénoxy thiénoisoxazole, utiles en tant qu'antagonistes D4. Lesdits composés servent au traitement de conditions médicales induites par l'inhibition du récepteur D4. Ces conditions sont notamment: trouble d'hyperactivité avec déficit de l'attention, trouble de névrose obsessionnelle, psychoses, abus de substances psychoactives, dépendance vis-à-vis de certaines substances, maladie de Parkinson, parkinsonisme, dyskinésies tardives, syndrome de Gilles de la Tourette, trouble des conduites et trouble oppositionnel avec provocation. L'invention porte en outre sur une composition pharmaceutique, des intermédiaires et un procédé de fabrication de ladite classe de composés.
Ayers Timothy A.
Jurcak John G.
Lee George E.
Aventis Pharmaceuticals Inc.
Aventisub II Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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