C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/04 (2006.01) A61K 31/40 (2006.01) A61K 31/42 (2006.01) A61K 31/44 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) A61K 31/55 (2006.01) A61P 25/18 (2006.01) C07D 261/00 (2006.01) C07D 333/00 (2006.01) C07D 451/00 (2006.01) C07D 495/00 (2006.01) C07D 498/00 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2383340
The compounds are of the class thienoisoxazolyl- and thienylpyrrazolyl-phenoxy substituted propyl derivatives, useful as D4 antagonists. Said compounds are useful for the treatment of medical conditions mediated by inhibition of D4 receptor. These conditions comprise, for example, Attention Deficit Hyperactivity Disorder, Obsessive-Compulsive Disorder, Psychoses, Substance Abuse, Substance Dependence, Parkinson's Disease, Parkinsonism, Tardive Diskinesia, Gilles de la Tourette Syndrome, Conduct Disorder, and Oppositional Defiant Disorder. A further aspect of the invention is to provide a pharmaceutical composition, intermediates, and a method of making said class of compounds.
L'invention porte sur des composés de la classe des dérivés thiénoisoxazolyle et thiénylpyrrazolyle du propyle à substitution phénoxy utiles comme antagonistes du D¿4?. Lesdits composés servent au traitement des états morbides médiés par l'inhibition du récepteur D¿4?. Ces états comprennent par exemple: le déficit d'attention, les troubles d'hyperactivité, les névroses obséssionnelles-compulsives, les psychoses, les toxicomanies, la dépendance aux substances toxiques, la maladie de Parkinson, le parkinsonisme, la diskinésie tardive, le syndrome de Gilles de la Tourette, les troubles du comportement, et les troubles oppositionnels. Un autre aspect de l'invention porte sur des préparations pharmaceutiques, sur des intermédiaires, et sur un procédé d'obtention de cette classe de composés.
Fink David M.
Freed Brian S.
Hrib Nicholas J.
Kosley Raymond W. Jr.
Lee George E.
Aventis Pharmaceuticals Inc.
Aventisub II Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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