Thienopyridine compounds, their production and use

Details Thienopyridine compounds, their production and use Thienopyridine compounds, their production and use

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/435 (2006.01) C07D 221/00 (2006.01) C07D 333/00 (2006.01)

Patent

CA 2331399

The compound of the present invention possesses excellent gonadotropin- releasing hormone antagonizing activity, and is useful for preventing or treating sex hormone-dependent diseases, e.g., sex hormone-dependent cancers (e.g., prostatic cancer, uterine cancer, breast cancer, pituitary tumor), prostatic hypertrophy, hysteromyoma, endometriosis, precocious puberty, amenorrhea syndrome, multilocular ovary syndrome, pimples etc., or as a pregnancy regulator (e.g., contraceptive), infertility remedy or menstruation regulator.

Le composé de la présente invention possède une excellente activité antagoniste vis-à-vis de la gonadolibérine. Le composé est utile dans la prévention ou le traitement des maladies liées aux hormones sexuelles, notamment les cancers dépendant des hormones sexuelles (par exemple, le cancer de la prostate, le cancer du col de l'utérus, le cancer du sein, l'adénome hypophysaire), l'hypertrophie de la prostate, l'hystéromyome, l'endométriose, la puberté précoce, l'aménorrhée, le syndrome des ovaires polykystiques, les papules etc., ou comme régulateur de la fécondité (par exemple, contraceptif), remède contre la stérilité ou régulateur de la menstruation.

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