Thienopyridine derivative, quinoline derivatives,and...

Details Thienopyridine derivative, quinoline derivatives,and... Thienopyridine derivative, quinoline derivatives,and...

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61K 31/4709 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07D 401/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2603125

Compounds having an antitumor potency. There are provided compounds, and pharmaceutically acceptable salts and solvates thereof, the compounds represented by the formula: (I) wherein R1 is H or a substitutable unsaturated 5 or 6-membered heterocycle; R2 is H; X is CH or N; Z is O or S; E is either absent or a halogen, alkyl or alkoxy; J is S or O; and T is a phenyl, unsaturated 5 or 6-membered heterocycle, or unsaturated 9 or 10-membered two- ring carbocycle or heterocycle.

La présente invention se rapporte à des composés ayant une capacité antitumorale. Elle propose des composés, ainsi que leurs sels et produits de solvatation pharmaceutiquement acceptables, représentés par la formule (I) dans laquelle R1 est un H ou un hétérocycle à 5 ou 6 chaînons insaturé pouvant porter des substitutions ; R2 est un H ; X est un CH ou un N ; Z est un O ou un S ; E est soit absent, soit un halogène, un alkyle ou un alcoxy ; J est un S ou un O ; et T est un phényl, un hétérocycle à 5 ou 6 chaînons insaturé ou un hétérocycle ou un carbocycle à deux cycles à 9 ou 10 chaînons insaturé.

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