Thienopyridinone compounds and methods of treatment

Details Thienopyridinone compounds and methods of treatment Thienopyridinone compounds and methods of treatment

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/4545 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2567268

The invention relates to 5-HT receptor agonists and partial agonists. Novel thienopyridinone compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, nonulcer dyspepsia, depression, anxiety, urinary incontinence, migraine, arrhythmia, atrial fibrillation, ischemic stroke, gastritis, gastric emptying disorders, feeding disorders, gastrointestinal disorders, constipation, erectile dysfunction, and respiratory depression. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.

L'invention concerne des agonistes et agonistes partiels du récepteur du 5-HT. Elle concerne également de nouveaux composés de thiéno-pyridinone représentés par la formule I, ainsi que la synthèse et les utilisations associées en vue de traiter des maladies médiées directement ou indirectement par des récepteurs du 5-HT. Ces états englobent la maladie d'Alzheimer, les troubles cognitifs, le syndrome du côlon irritable, la nausée, les vomissements, la prokinésie, la maladie des reflux gastro-oesophagiens, la dyspepsie sans ulcère, la dépression, l'anxiété, l'incontinence urinaire, la migraine, l'arythmie, la fibrillation auriculaire, l'accident ischémique cérébrale, la gastrite, les troubles de vidange gastrique, les troubles de l'alimentation, les troubles gastro-intestinaux, la constipation, le dysérection et la dépression respiratoire. L'invention concerne également des procédés de préparation associés ainsi que de nouveaux intermédiaires et leurs sels pharmaceutiques.

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