C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/429 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2600175
Inhibitors of macrophage migration inhibitory factor having a thienopyridinone backbone are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with macrophage migration inhibitory factor activity. The inhibitors of macrophage migration inhibitory factor have the following structures formula (I), (II), (III) including forms such as stereoisomers, free forms, pharmaceutically acceptable salts or esters thereof, solvates, or combinations of such forms, wherein n, R1, R2, R3, X, and Y are as defined herein. Compositions comprising an inhibitor of macrophage migration inhibitory factor in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
L'invention se rapporte à des inhibiteurs du facteur d'inhibition de la migration des macrophages comprenant un squelette thiénopyridinone. Ces inhibiteurs peuvent servir à traiter une variété de troubles, y compris des états pathologiques associés à l'activité du facteur d'inhibition de la migration des macrophages. L'invention concerne des inhibiteurs de formules (I), (II), (III), dans lesquelles n, R1, R2, R3, X, et Y sont tels que définis dans la description, ainsi que des formes de type stéréo-isomères, des formes libres, des sels pharmaceutiquement acceptables, ou des esters de ces inhibiteurs, et des solvates, ou des combinaisons desdites formes. La présente invention concerne en outre des compositions comprenant un inhibiteur du facteur d'inhibition de la migration des macrophages, en association avec un vecteur pharmaceutiquement acceptable, ainsi que des procédés d'utilisation correspondants.
Davis Timothy James
Kumar K. C. Sunil
Sircar Jagadish
Ying Wenbin
Avanir Pharmaceuticals
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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