C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61P 13/10 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2590585
The present invention discloses fused thienopyridyl compounds of general formula (I), wherein X1-X6, R5-R7, Z1 and L are as defined in the description. The resent invention also discloses a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain, urinary incontinence, bladder overactivity, and inflammatory thermal hyperalgesia in mammals, and pharmaceutical compositions including those compounds.
Cette invention concerne des composés fondus de thiénopyridyle représentés par la formule générale (I), dans laquelle X1-X6, R5-R7, Z1 et L sont tels que définis dans la description. Cette invention concerne également une procédé d'inhibition du récepteur VR1 chez des mammifères au moyen de ces composés, un procédé permettant de maîtriser la douleur, l'incontinence urinaire, l hyperactivité vésicale et l'hyperalgie thermique inflammatoire chez des mammifères et sur des compositions pharmaceutiques renfermant ces composés.
Gomtsyan Arthur R.
Jinkerson Tammie K.
Lee Chih-Hung
Turner Sean C.
Abbott Laboratories
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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