C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61K 31/519 (2006.01)
Patent
CA 2611587
The invention is directed to thienopyrimidines and thienopyridines compounds of Formula I and Formula II: where R1, R3, B, Z, Q, p, q and X are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of FLT3, the use of such compounds to reduce or inhibit kinase activity of FLT3 in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
L'invention concerne des thienopyrimidines et des composés de thienopyridines ayant les formules I et II dans lesquelles R1, R3, B, Z, Q, p, q et X sont définis dans la description, ainsi que l'utilisation de ces composés en tant que modulateurs de la protéine tyrosine kinase, notamment les inhibiteurs de FLT3, l'utilisation de ces composés visant à réduire ou à inhiber l'activité de kinase de FLT3 dans une cellule ou chez un sujet, et l'utilisation de ces composés dans la prévention ou le traitement chez un sujet d'un ou de plusieurs troubles proliférants cellulaires liés à FLT3. L'invention concerne également des compositions pharmaceutiques comprenant les composés de la présente invention et des procédés pour traiter des états tels que les cancers ou d'autres troubles proliférants cellulaires.
Baumann Christian Andrew
Gaul Michael David
Kreutter Kevin Douglas
Janssen Pharmaceutica N.v.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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