Thienopyrimidine-based inhibitors of the src family

Details Thienopyrimidine-based inhibitors of the src family Thienopyrimidine-based inhibitors of the src family

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/38 (2006.01) A61K 31/519 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C07D 239/00 (2006.01) C07D 333/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2426775

Various thienopyrimidine-based analog compounds are able to selectively inhibit the Src family of tyrosine kinases. These compounds are useful in the treatment of various diseases including hyperproliferative diseases, hematologic diseases, osteoporosis, neurological diseases, autoimmune diseases, allergic/immunological diseases, or viral infections. Embodiments of the invention are compounds of the formulae (A),(B) and (C)

L'invention concerne divers composés analogues à base de thiénopyrimidine capables d'inhiber sélectivement les tyrosine kinases de la famille Src. Ces composés sont utiles pour le traitement de diverses maladies, notamment les maladies hyperprolifératives, les maladies hématologiques, l'ostéoporose, les maladies neurologiques, les maladies auto-immunes, les maladies allergiques/immunologiques ou les infections virales.

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