C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/519 (2006.01) A61P 9/08 (2006.01) A61P 43/00 (2006.01) C07D 495/14 (2006.01)
Patent
CA 2365578
Thieno[2,3-d]pyrimidine compounds of general formula (1) useful as drugs having a cGMP-specific phosphodiesterase inhibiting effect and so on; and a process for the preparation of the same wherein Q is a group represented by the general formula: (CH2)n-N(r1)-C(r2)(r3), CH=CH-CH=CH, or (CH2)m which is bonded to a and b; R1 is hydrogen or C1-C6 alkyl; R2 is C3-C8 cycloalkyl optionally substituted with G1, phenyl optionally substituted with G2, or a saturated or unsaturated heterocyclic group having 1 to 4 heteroatoms selected from among N, O and S and being optionally substituted with G3; and R3 is a saturated or unsaturated heterocyclic group having 1 to 4 heteroatoms selected from among N, O and S and being optionally substituted with G3 or a group represented by the general formula: (CH2)kC(=O)R4 or CH=CHC(O)R4.
L'invention concerne des composés de thiéno[2,3-d]pyrimidine de la formule générale (1), qui sont utiles en tant que médicaments ayant un effet d'inhibition de la phosphodiestérase spécifique au cGMP, etc., et un procédé de préparation desdits composés. Dans ladite formule, Q est un groupe de la formule générale (CH¿2?)¿n?-N(r¿1?)-C(r¿2?)(r¿3?), CH=CH-CH=CH, ou (CH¿2?)¿m? lequel est lié à a et b; R¿1? est hydrogène ou alkyle C¿1?-C¿6?; R¿2? est cycloalkyle C¿3?-C¿8? éventuellement substitué par G¿1?, phényle éventuellement substitué par G¿2?, ou un groupe hétérocyclique saturé ou insaturé comprenant 1 à 4 hétéroatomes choisis entre N, O et S et éventuellement substitué par G¿3? ou un groupe de la formule générale (CH¿2?)¿k?C(=O)R¿4? ou CH=CHC(O)R¿4?.
Horikoshi Hiromi
Mochizuki Nobuo
Shiinoki Yasuyuki
Uchida Seiichi
Umeda Nobuhiro
Borden Ladner Gervais Llp
Nippon Soda Co. Ltd.
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