Thienopyrimidines useful as aurora kinase inhibitors

Details Thienopyrimidines useful as aurora kinase inhibitors Thienopyrimidines useful as aurora kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/519 (2006.01)

Patent

CA 2573999

The present invention provides compounds having the formula (I) wherein R1, R2, X1, X2, L1, L2, Y and Z are as defined in classes and subclasse herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as inhibitors of protein kinase (e.g., Aurora), and thus are useful, for example, for the treatment of Aurora mediated diseases.

La présente invention prévoit des composés de formule (I) R1, R2, X1, X2, L1, L2, Y et Z étant définis ici dans des classes et des sous-classes, et des compositions pharmaceutiques de ceux-ci, tel que décrit généralement et dans les présentes sous-classes, lesquels composés sont utiles en tant qu'inhibiteurs de la protéine kinase (par exemple, Aurora) et sont donc utiles pour le traitement de maladies médiées par Aurora.

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