Thienopyrimidinone derivatives as melanin concentrating...

Details Thienopyrimidinone derivatives as melanin concentrating... Thienopyrimidinone derivatives as melanin concentrating...

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/522 (2006.01) A61P 5/00 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2627653

The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression or anxiety by administration of a therapeutically effective dose of a compound according to Formula I.

L'invention concerne des composés comprenant tous les stéréoisomères, les solvates, les promédicaments et leurs formes pharmaceutiquement acceptables de formule (I). L'invention concerne, de plus, des compositions pharmaceutiques contenant au moins un composé de formule (I) et éventuellement au moins un agent thérapeutique supplémentaire. Enfin, l'invention concerne des méthodes pour traiter un patient souffrant d'une maladie ou des troubles modulés par la MCHR-1, tels que l'obésité, le diabète, la dépression ou l'anxiété comprenant l'administration d'une dose à efficacité thérapeutique du composé de formule (I).

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