Thienopyrimidinones for treatment of inflammatory disorders...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 495/04 (2006.01) A61K 31/519 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2669399

The current invention provides compounds of formula (1): wherein: one of Q1, Q2 and Q3 is S, and the other of two of Q1, Q2 and Q3 are -CR1-, which are inhibitors of PI3K-delta. These compounds are useful for treatment of conditions mediated by PI3K-delta, such as hematopoietic cancers, immune disorders, and bone resorption disorders. The invention further provides pharmaceutical compositions comprising a compound of formula (1) and methods of using these compounds and compositions to treat conditions mediated by PI3K-delta.

La présente invention propose des composés représentés par la formule (1), dans laquelle l'un de Q1, Q2 et Q3 est S, et l'un des deux autres de Q1, Q2 et Q3 est -CR1-, qui sont des inhibiteurs de PI3K-delta. Ces composés sont utiles pour le traitement d'affections facilitées par le PI3K-delta, telles que des cancers hématopoïétiques, des troubles immunitaires et des troubles de la résorption osseuse. L'invention propose également des compositions pharmaceutiques comportant un composé représenté par la formule (1) et des procédés d'utilisation de ces composés et de ces compositions pour traiter des affections facilitées par le PI3K-delta.

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