(thio)carbimidinic acid derivatives and pharmaceutical...

C - Chemistry – Metallurgy – 07 – C

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Details

C07C 335/28 (2006.01) A61K 31/17 (2006.01) A61K 31/21 (2006.01) A61K 31/26 (2006.01) A61K 31/275 (2006.01) A61K 31/33 (2006.01) A61K 31/38 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) C07C 275/60 (2006.01) C07C 279/24 (2006.01) C07C 279/26 (2006.01) C07D 213/30 (2006.01) C07D 213/75 (2006.01) C07D 233/64 (2006.01) C07D 239/42 (2006.01) C07D 295/088 (2006.01) C07D 307/66 (2006.01) C07D 333/36 (2006.01)

Patent

CA 2168231

The present invention concerns new pharmaceutical agents containing (thio)carbimidinic acid derivatives of formula I. In addition the invention concerns new (thio)carbimidinic acid derivatives, processes for the production thereof and pharmaceutical agents containing these compounds. The invention concerns pharmaceutical agents containing at least one (thio)carbimidinic acid derivative of formula I as the active substance Image (I), in which R denotes an aliphatic residue or an optionally substituted phenyl group or a carbocyclic group with 7-15 C atoms or a heterocyclic ring system in which the carbocycles and heterocyles can be partially or completely hydrogenated, R1 can be phenyl, phenyl C1-C6-alkyl, hetaryl or hetaryl-C1-C6-alkyl, wherein these residues can be optionally substituted once or several times, R2 denotes hydrogen, C1-C6 alkyl, C1-C6 alkoxy, cyano, amino or hydroxy X denotes oxygen, sulphur or NR2 and Y denotes oxygen or sulphur as well as tautomers, enantiomers and diastereomers and physiologically tolerated salts thereof.

L'invention concerne de nouveaux médicaments qui contiennent des dérivés d'acide (thio)carbamidinique répondant à la formule (I), de nouveaux dérivés d'acide (thio)carbamidinique, leur procédé de préparation et des médicaments conteant ces composés. L'invention porte sur des médicaments qui contiennent en tant que principe actif au moins un dérivé d'acide (thio)carbamidinique répondant à la formule (I), dans laquelle R désigne un reste aliphatique, un groupe phényle éventuellement substitué, un groupe carbocyclique ayant de 7 à 15 atomes de carbone, ou un système hétérocyclique, les carbocycles et les hétérocycles pouvant être entièrement ou partiellemnt hydratés; R<1> désigne phényle, phénylalkyle-C1-C6, hétaryle, ou hétarylalkyle-C1-C6, ces restes pouvant être substitués une ou plusieurs fois; R<2> désigne hydrogène, alkyle C<1>-C6, alcoxy C1-C6, cyano, amino ou hydroxy; X désigne oxygène, soufre ou NR<2>; et Y désigne oxygène ou soufre. L'invention concerne également les tautomères, énantiomères, diastéréomères et sels physiologiquement acceptables de tels dérivés.

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