Thio etianic acid derivatives

Details Thio etianic acid derivatives Thio etianic acid derivatives

C - Chemistry, Metallurgy

07

J

260/15, 260/81

C07J 31/00 (2006.01) C07J 3/00 (2006.01) C07J 71/00 (2006.01)

Patent

CA 1134345

Abstract of the Disclosure Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4- diene 17.beta.-thiocarboxylic acid esters are useful as anti- inflammatory steroids. These compounds are optionally substituted at the 6.alpha. - position with fluoro or chloro; optionally substituted at the 9.alpha. position with fluoro, chloro or bromo; substituted at the 11 position with a keto, a .beta.-hydroxy or a .beta.-chloro (the latter only when there is a 9.alpha.-chloro); substituted at 16.alpha., 17.alpha. - positions with isopropylidenedioxy; and substituted at 16.alpha. (or 16.beta.) with methyl or hydrogen when there is a 17.alpha.-hydroxy (or an ester).

324557

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