Thio-substituted arylmethanesulfinyl derivatives

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 323/52 (2006.01) A61K 31/10 (2006.01) A61P 43/00 (2006.01) C07C 317/18 (2006.01) C07C 317/44 (2006.01) C07C 323/07 (2006.01) C07C 323/60 (2006.01) C07D 211/46 (2006.01) C07D 295/18 (2006.01) C07D 295/20 (2006.01) C07D 307/52 (2006.01) C07D 307/68 (2006.01) C07D 333/20 (2006.01) C07D 333/38 (2006.01)

Patent

CA 2562554

The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of compounds of Formula (A): wherein Ar, X, Y, R1, R2, R3, and q are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness, promotion of wakefulness, treatment of Parkinson's disease, cerebral ischemia, stroke, sleep apneas, eating disorders, stimulation of appetite and weight gain, treatment of attention deficit hyperactivity disorder ("ADHD"), enhancing function in disorders associated with hypofunctionality of the cerebral cortex, including, but not limited to, depression, schizophrenia, fatigue, in particular, fatigue associated with neurologic disease, such as multiple sclerosis, chronic fatigue syndrome, and improvement of cognitive dysfunction.

Cette invention se rapporte à des compositions chimiques, à des procédés pour la préparation et à des utilisations de ces compositions. Cette invention concerne en particulier des compositions de composés représentés par la formule (A), dans laquelle Ar, X, Y, R?1¿, R?2¿, R?3¿et q sont tels que définis dans les pièces descriptibles de la demande; et à leur utilisation dans les traitements de maladies, tels que le traitement de la somnolence, la stimulation de l'état d'éveil, le traitement de la maladie de Parkinson, de l'ischémie cérébrale, de l'accident vasculaire cérébral, des apnées du sommeil, des troubles de l'alimentation, de la stimulation de l'appétit et de la prise de poids, du trouble d'hyperactivité avec déficit de l'attention (THADA), et l'amélioration de la fonction dans des troubles associés à une hypofonctionalité du cortex cérébral, telle que notamment la dépression, la schizophrénie, la fatigue et notamment la fatigue associée à une maladie neurologique, telle que la sclérose en plaques, le syndrome de fatigue chronique, et l'amélioration de la fonction cognitive.

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